Nociceptive stimulation

DYNAMIC PLANTAR AESTHESIOMETER
Cat. No. 37400

The Dynamic Plantar Aesthesiometer consists of a movable force-actuator below a network platform upon which the operator deposits the rodent (either mouse or rats). A Perspex enclosure renders the animal unrestrained for the duration of the experiment. The operator places the actuator beneath the paw (proper placement ensured via an angled mirror). A Von Frey - type filament exerts an increasing force to the plantar surface, starting below the threshold of detection and increasing until the animal removes its paw. At the retraction reflex movement when the paw is withdrawn, the 3740 registers and displays then actual force at which paw withdrawal occurred.

PLETHYSMOMETER
Cat. No. 7140

The new Plethysmometer is a micro-controlled volume meter, specially designed for accurate measurement of the rat/mouse paw swelling. It consists of a water filled Perspex cell (several diams. are available for either rats or mice) into which the paw is dipped. A transducer of original design records small differences in water level, caused by volume displacement. The digital read-out shows the exact volume of the paw. The instruments features direct connection to PC via the optional WinDAS software package. The optional Mini-Printer 7145 enables the print-out of the experimental data.

ANALGESY-METER
Cat No. 37215

The 37215 is the up to date of the classical 7200 which, since 1965, in a number of academic and industrial laboratories, is helping to perform a rapid precise screening and analgesic drugs, according to Randall-Selitto Test. The 37215 features a weight displacing screw driven by a low voltage geared motor, to increase safety, an optical switch to measure the start/stop time-lag (hence the force at which the animal struggles) and to communicate this datum to the Multifunction Printer. Provision is made for easier and quicker replacement of parts; mains & pedal cables are now detachable, etc.

HOT/COLD PLATE
Cat. No. 35100

This new instrument can be used as a conventional HOT PLATE, to carry out a rapid precise screening of narcotic type analgesic drugs according to the Hot Plate Test devised by N.B. Eddy and D. Leinbach. and as COLD PLATE. The Cold Plate Test is useful in studying the traditional cold receptors The multifunction liquidcrystal graphic-display monitors the plate temperature in 0.1°C steps and shows the reaction time in 0.1 s increments on the graphic display. The plate temperature can be set by the operator in the range 2-66°C. The 35100 is a microprocessor controlled unit. The experimental data can be directly exported to the PC USB or serial ports. Communication is managed by the dedicated CUB Data Acquisition Software Package, Cat. 52050-11, included as standard. The 35100 is provided with a memory key, for data portability.

TAIL FLICK UNIT
Cat. No. 37360

This new style Tail Flick Unit has been designed to perform rapid precise screening of analgesic drugs on the rat tail, according to D'Amour & Smith. It basically consists of an I.R. source, whose radiant energy of adjustable intensity is focused on the rat tail. The rat is held by the operator on the instrument unobstructed upper panel in such a way that its tail, placed over a flush mounted window, receives the I.R. energy. An optional holder is available to be used with the mouse. When the animal feels pain and flicks its tail, the instrument automatically detects the withdrawal latency to the nearest 0.1 s. The 37360 is a microprocessor controlled unit. The experimental data can be directly exported to the PC USB or serial ports. Communication is managed by the dedicated CUB Data Acquisition Software Package, Cat. 52050-09, included as standard. The 37360 is provided with a memory key, for data portability.

HEAT-FLUX I.R. RADIOMETER
Cat. No. 37300

The Heat-Flux I.R. Radiometer Cat. 37300 has been designed to calibrate I.R. sources, in particular the classic Tail-Flick Cat. 7360 & Plantar Test Cat 7370 of our make, i.e., to make sure they deliver the same power flux (expressed in mW per square cm) and hence a nociceptive stimulus of the same intensity. The standard package of this extremely useful accessory is complete with I.R. Probe, Digital Meter, Adaptors for Tail-Flick and Plantar Test (see picture), all parts of this portable self-sufficient instrument neatly lodged in a sturdy plastic case with punched foam lining.

PLANTAR TEST
Cat. No. 37370 / 37380

The Plantar Test represents a remarkable advance in determination of acute nociceptive thermal threshold in laboratory animals, as it combines the best features of all other methods of measuring pain sensitivity. Unique to the Plantar Test, the animal is unrestrained and unhandled during experiments. The 37370 basically consists of a movable I.R. source which the operator glides below a glass pane, upon which a 3-compartment enclosure for rat is positioned; in alternative a 6-compartment enclosure, more convenient for the mouse. The model for mouse is Cat. No. 37380. When the rat feels pain and withdraws its paw, the instrument automatically detects the withdrawal latency to the nearest 0.1s. The 37370 is a microprocessor controlled unit. The experimental data can be directly exported to the PC USB or serial ports. Communication is managed by the dedicated CUB Data Acquisition Software Package, Cat. 52050-10, included as standard. The 37370 is provided with a memory key, for data portability.